Background: It is plausible that interleukin polymorphisms may affect predisposition of autoimmune disorders such as systemic lupus erythematosus (SLE), but the results of so far published studies remain controversial. Objectives: The authors conducted this meta-analysis to clarify relationships between interleukin-1 (IL-1)/interleukin-4 (IL-4)/interleukin-6 (IL-6)/interleukin-10 (IL-10) polymorphisms and SLE by pooling the findings of eligible studies. Methods: A comprehensive search of PubMed, EMBASE, Web of Science, and CNKI was endorsed by the authors to identify already published studies. Fifty-seven studies were found to be eligible for meta-analyses. Results: The overall pooled meta-analyses yielded positive findings for IL-1A −889 C/T, IL-1B −31 T/C, IL-6 −174 G/C, IL-4 −590 C/T, and IL-10 −1,082 A/G polymorphisms. In addition, we also detected similar positive findings for IL-1B −511 C/T, IL-4 −590 C/T, IL-10 −592 A/C, IL-10 −819 C/T, and IL-10 −1,082 A/G polymorphisms in Asians, and such positive findings were also observed for IL-1A −889 C/T, IL-6 −174 G/C, and IL-10 −1,082 A/G polymorphisms in Caucasians. Conclusions: The meta-analyses’ results suggest that IL-1A −889 C/T, IL-1B −31 T/C, IL-6 −174 G/C, IL-4 −590 C/T, and IL-10 −1,082 A/G polymorphisms might affect predisposition of SLE.
Int Arch Allergy Immunol

中文翻译：

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系统性红斑狼疮的白介素多态性和易感性：荟萃分析

背景：白细胞介素多态性可能会影响自身免疫性疾病（如系统性红斑狼疮 (SLE)）的易感性是合理的，但迄今为止已发表的研究结果仍存在争议。目的：作者进行了这项荟萃分析，以阐明白介素 1 ( IL-1 ) /白介素 4 ( IL-4 ) /白介素 6 ( IL-6 ) /白介素 10 ( IL-10 ) 多态性和SLE 通过汇集符合条件的研究结果。方法：作者同意对 PubMed、EMBASE、Web of Science 和 CNKI 进行全面搜索，以识别已发表的研究。发现 57 项研究符合荟萃分析的条件。结果：总体汇总荟萃分析得出了IL-1A -889 C/T、IL-1B -31 T/C、IL-6 -174 G/C、IL-4 -590 C/T 和IL 的阳性结果-10 -1,082 A/G 多态性。此外，我们还检测到IL-1B -511 C/T、IL-4 -590 C/T、IL-10 -592 A/C、IL-10 -819 C/T 和IL-10 的类似阳性结果-1,082 A/G 多态性在亚洲人中，并且对于白种人中的IL-1A -889 C/T、IL-6 -174 G/C 和IL-10 -1,082 A/G 多态性也观察到了这种阳性结果。结论：荟萃分析的结果表明IL-1A -889 C/T、IL-1B -31 T/C、IL-6 -174 G/C、IL-4 -590 C/T 和IL-10 −1,082 A/G 多态性可能会影响 SLE 的易感性。
Int Arch 过敏免疫