Introduction: We evaluated the prognostic significance of the preoperative albumin-to-globulin ratio (AGR) in patients with hepatocellular carcinoma (HCC) with various liver etiologies. Methods: We retrospectively analyzed 157 patients with HCC between July 2010 and February 2021. The relationship between clinicopathological variables was investigated using univariate and multivariate analyses. Statistical significance was set at p #x3c; 0.05. Results: The mean overall survival (OS) was 24.5 months. The 1-, 3-, and 5-year OS rates were 90.4%, 81.2%, and 68.7%, respectively. Patients were classified into 2 groups: AGR #x3c;1.16 (low-AGR group; n = 43) and AGR ≥1.16 (high-AGR group; n = 114). In univariate analysis, OS was significantly reduced in patients with a low AGR (AGR #x3c;1.16), an alpha-fetoprotein level ≥25 ng/mL, a tumor size ≥3.5 cm, microvascular invasion, and poor tumor differentiation. In multivariate analysis, a low AGR (hazard ratio [95% confidence interval]) (2.394 [1.092–5.213]; p = 0.030) and microvascular invasion (2.268 [1.019–5.169]; p = 0.045) were independent predictors of OS. Discussion/Conclusion: A low AGR was significantly associated with poor OS in patients with HCC, regardless of liver etiology. This may assist in treatment stratification and better management of patients with HCC.
Dig Surg

中文翻译：

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术前白蛋白与球蛋白比率预测肝细胞癌的预后：一项包括非肝炎病毒感染患者的队列研究

简介：我们评估了术前白蛋白与球蛋白比率 (AGR) 对各种肝脏病因的肝细胞癌 (HCC) 患者的预后意义。方法：我们回顾性分析了 2010 年 7 月至 2021 年 2 月期间的 157 名 HCC 患者。使用单变量和多变量分析研究了临床病理变量之间的关系。统计显着性设置为p #x3c；0.05。结果：平均总生存期 (OS) 为 24.5 个月。1 年、3 年和 5 年 OS 率分别为 90.4%、81.2% 和 68.7%。患者分为 2 组：AGR #x3c；1.16（低 AGR 组； n = 43）和 AGR ≥1.16（高 AGR 组； n= 114）。在单变量分析中，低 AGR (AGR #x3c;1.16)、甲胎蛋白水平≥25 ng/mL、肿瘤大小≥3.5 cm、微血管浸润和肿瘤分化差的患者的 OS 显着降低。在多变量分析中，低 AGR（风险比 [95% 置信区间]）（2.394 [1.092–5.213]；p = 0.030）和微血管侵犯（2.268 [1.019–5.169]；p = 0.045）是 OS 的独立预测因子。讨论/结论：无论肝病病因如何，低 AGR 与 HCC 患者的不良 OS 显着相关。这可能有助于治疗分层和更好地管理 HCC 患者。
挖掘外科