Précis: 

Compared with normal subjects with similar shallow anterior chamber depth (ACD), patients with primary angle closure disease (PACD) had narrower angle structures measured by swept-source optical coherence tomography (SS-OCT) at 250 μm from scleral spur (very root of iris), especially along oblique and vertical axis.

Purpose: 

To examine anterior segment structures in normal subjects whose ACD was shallow on slit-lamp examination but did not meet the diagnostic criteria of PACD, and to compare them with PACD patients with similar ACD.

Materials and Methods: 

Patients were recruited from glaucoma clinic at Zhongshan Ophthalmic Center. A total of 40 eyes from 29 PACD patients and 40 eyes from 34 normal subjects received full ophthalmic examination and CASIA SS-1000 OCT tests. PACD eyes and control eyes were 1:1 matched for ACD at 0 degree of scan. Generalized linear model that accounted for inter-eye correlation was used to compare differences between the 2 groups for intraocular pressure and SS-OCT parameters. P-values were adjusted for multiple comparisons using the Bonferroni method.

Results: 

The PACD and control groups had similar age, but the PACD group had a significantly higher intraocular pressure (18.4 vs. 14.0 mm Hg, P=0.005). Angle parameters, representative of angle area, such as angle recess area and trabecular iris space area measured at 250 μm along axes of 90, 135, 225, and 315 degrees were significantly smaller in PACD group than those of control group (adjusted P<0.05), while most of angle parameters at 500 and 750 μm, volume parameters, and anterior chamber parameters, were similar (adjusted P>0.05).

Conclusions: 

In PACD patients compared with normal subjects with similar anterior chamber shallowing, OCT findings measured at the iris root 250 μm from the scleral spur, especially in the oblique and vertical axes, including angle recess area and trabecular iris space area, may match gonioscopic findings more closely and provide further insight into mechanisms of PACD.

中文翻译：

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原发性房角闭合性疾病的眼前节OCT与浅前房相似的正常人的比较

概要： 

与具有相似浅前房深度（ACD）的正常受试者相比，原发性闭角病（PACD）患者在距巩膜骨刺（巩膜根部）250μm处通过扫源光学相干断层扫描（ SS-OCT）测量具有更窄的房角结构。虹膜），特别是沿斜轴和垂直轴。

目的： 

目的：检查裂隙灯检查ACD浅但不符合PACD诊断标准的正常人眼前节结构，并与ACD相似的PACD患者进行比较。

材料和方法： 

患者是从中山眼科中心青光眼诊所招募的。29 名 PACD 患者的 40 只眼睛和 34 名正常受试者的 40 只眼睛接受了全面的眼科检查和 CASIA SS-1000 OCT 测试。PACD 眼和对照眼在 0 度扫描下以 1:1 的比例匹配 ACD。使用考虑眼间相关性的广义线性模型来比较两组之间眼压和SS-OCT参数的差异。使用 Bonferroni 方法调整P值以进行多重比较。

结果： 

PACD组和对照组年龄相似，但PACD组眼压显着升高（18.4 vs. 14.0 mm Hg，P =0.005）。PACD组在250 μm处沿90、135、225、315度轴测得的代表角度面积的角度参数，如角度凹陷面积和小梁虹膜间隙面积均显着小于对照组（调整后P< 0.05） ），而 500 和 750 μm 处的大部分角度参数、体积参数和前房参数相似（调整后P >0.05）。

结论： 

PACD患者与前房变浅相似的正常人相比，在距离巩膜刺250μm的虹膜根处测量的OCT结果，特别是在斜轴和垂直轴上，包括角隐窝区域和小梁虹膜间隙区域，可能与房角镜检查结果更加匹配密切关注并提供对 PACD 机制的进一步见解。