Eosinophilic myocarditis is a clinical condition whereby myocardial injury is mediated by eosinophilic infiltration. A number of underlying causes, including reactive, clonal, or idiopathic hypereosinophilic syndrome, may trigger eosinophilia. Disease presentation may vary from mild subclinical variants to fulminant myocarditis with thromboembolic complications, and in some cases, endomyocardial and valvular fibrosis may be seen. A detailed examination coupled with the use of multimodality imaging, and endomyocardial biopsy may help establish diagnosis. Treatment is aimed at symptomatic management and treating the underlying cause of eosinophilia, such as withdrawal of implicated drugs, antihelminthic therapy for infection, immunosuppression for autoimmune conditions, and targeted therapy with tyrosine kinase inhibitors in cases with clonal myeloid disorders.

嗜酸性粒细胞性心肌炎是一种由嗜酸性粒细胞浸润介导的心肌损伤的临床病症。许多潜在原因，包括反应性、克隆性或特发性嗜酸性粒细胞增多综合征，都可能引发嗜酸性粒细胞增多。疾病表现可能有所不同，从轻微的亚临床变异到伴有血栓栓塞并发症的暴发性心肌炎，在某些情况下，可能会出现心内膜心肌和瓣膜纤维化。详细检查结合多模态成像和心内膜心肌活检可能有助于确诊。治疗的目的是对症管理和治疗嗜酸性粒细胞增多的根本原因，例如停用相关药物、针对感染进行抗蠕虫治疗、针对自身免疫性疾病进行免疫抑制，以及在克隆性骨髓疾病病例中使用酪氨酸激酶抑制剂进行靶向治疗。