Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives,European Journal of Organic Chemistry

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Applications of Purine Ring Opening in the Synthesis of Imidazole, Pyrimidine, and New Purine Derivatives
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-08-10 , DOI: 10.1002/ejoc.202100755
Kristaps Leškovskis ₁ , Jānis Miķelis Zaķis ₁ , Irina Novosjolova ₁ , Māris Turks ₂

Affiliation

The ring system of purine is remarkably stable, but can be opened at either side, if properly activated. In this review, purine ring opening reactions leading to imidazole and pyrimidine derivatives are summarized. Purine ring opening is also a powerful tool for the synthesis of new ring-modified purine derivatives (e. g., N1-labelled analogs) by various rearrangement pathways.