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Clinical characteristics of children with Guillain-Barré syndrome and factors associated with disease severity
Journal of Clinical Neuroscience ( IF 1.9 ) Pub Date : 2021-08-09 , DOI: 10.1016/j.jocn.2021.08.001
Han-Yu Luo 1 , Xiu-Juan Li 1 , Min Cheng 1 , Juan Wang 1 , Ling-Ling Xie 1 , Zheng-Xiong Yao 1 , Li Jiang 1
Affiliation  

Guillain-Barré syndrome (GBS) is the leading cause of pediatric acute flaccid paralysis.

This study aimed to summarize the clinical features of children with GBS and to explore factors associated with the severity of weakness. One hundred and twenty-two children with GBS (73 males and 49 females) were retrospectively analysed. The median age (IQR) at diagnosis was 4.0 years (2.9–7.2 years), and 26.2% of patients were at the age of 2–3 years. Of the 122 cases, 71 (58.2%) had an antecedent infection, 58 (47.5%) had cranial nerve involvement, 36 (29.1%) had dysautonomia, 77 (63.1%) had sensory symptoms, 28 (23.0%) had difficulty in breathing of which 15 (12.3%) patients required mechanical ventilation, and 8 (6.6%) had normal tendon reflex or hyperreflexia. Cytoalbuminologic dissociation of the cerebrospinal fluid was observed in 97 cases (82.9%). Further, 120 patients underwent nerve conduction studies: 76 (63.3%) exhibited demyelinating features whereas 36 (30.0%) had axonal type of CBS. 70.2% of patients could walk independently at 12 weeks. Fourteen (11.5%) patients were classified into the mild group [GBS disability score (GBS-DS) < 3] and 108 (88.5%) were classified into the severe group (GBS-DS ≥ 3). The incidence of cranial involvement (P = 0.038) and decreased tendon reflexes (P = 0.048) were significantly different between the two groups. These findings suggested that cranial nerve involvement is associated with severe muscle weakness in children with GBS.



中文翻译:

吉兰-巴雷综合征患儿的临床特征及疾病严重程度的相关因素

格林-巴利综合征 (GBS) 是小儿急性弛缓性麻痹的主要原因。

本研究旨在总结 GBS 儿童的临床特征,并探讨与虚弱严重程度相关的因素。回顾性分析了 122 名 GBS 儿童(73 名男性和 49 名女性)。诊断时的中位年龄 (IQR) 为 4.0 岁(2.9-7.2 岁),26.2% 的患者年龄在 2-3 岁之间。122例中,71例(58.2%)有先行感染,58例(47.5%)有颅神经受累,36例(29.1%)有自主神经功能障碍,77例(63.1%)有感觉症状,28例(23.0%)有困难呼吸,其中15(12.3%)名患者需要机械通气,8名(6.6%)患者腱反射正常或反射亢进。在 97 例 (82.9%) 中观察到脑脊液的细胞白蛋白分离。此外,120 名患者接受了神经传导研究:76 (63. 3%) 表现出脱髓鞘特征,而 36 (30.0%) 具有轴突型 CBS。70.2% 的患者在 12 周时可以独立行走。14 名 (11.5%) 患者被分为轻度组 [GBS 残疾评分 (GBS-DS) < 3],108 名 (88.5%) 患者被分为重度组 (GBS-DS ≥ 3)。两组间颅骨受累(P = 0.038)和腱反射减弱(P = 0.048)的发生率有显着差异。这些发现表明,脑神经受累与 GBS 儿童的严重肌肉无力有关。两组间颅骨受累(P = 0.038)和腱反射减弱(P = 0.048)的发生率有显着差异。这些发现表明,脑神经受累与 GBS 儿童的严重肌肉无力有关。两组间颅骨受累(P = 0.038)和腱反射减弱(P = 0.048)的发生率有显着差异。这些发现表明,脑神经受累与 GBS 儿童的严重肌肉无力有关。

更新日期:2021-08-10
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