Cellulose ( IF 4.9 ) Pub Date : 2021-08-06 , DOI: 10.1007/s10570-021-04104-1 Alice Paprskářová 1 , Pavel Suchý 1, 2 , Marta Chalupová 1, 2 , Jarmila Klusáková 1, 2 , Lenka Michlovská 3 , Lucy Vojtová 3 , Tomáš Sopuch 4
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Different topical hemostatic materials are used to achieve effective hemostasis. High hemostatic activity, biocompatibility, bioresorbability, and easy manipulation are to be expected in such a developed product. In the surgical world with these specific requirements, finding a proper hemostatic agent is very difficult. The study compared several materials of various construction properties, which were assessed for structural and related properties by morphological analyses and assessed in vivo for their efficiency and behaviour using a model of rat partial nephrectomy. New sodium salt of carboxymethyl cellulose (CMC) sponge with the lowest porosity and free swell absorptive capacity contained the highest amount of hydroxyl and carboxyl groups. Results revealed that this CMC material in the form of a bioresorbable sponge may ensure the necessary hemostatic effects, while also providing a positive influence on the reaction of the local tissue. The CMC material also needed significantly less time to achieve hemostasis (p < 0.001). Moreover, the sponge reached satisfactory results in the histopathological evaluation with the lowest destruction score and favorable healing reaction. This modified product proved itself to be a promising bioresorbable hemostat, which, according to its design, matches with its surgical applications. In general, the obtained data elucidated the dependency of the total effect on its structure and composition.
Graphic abstract
中文翻译：
大鼠肾脏模型中结构不同的纤维素类止血剂的评价和比较
使用不同的局部止血材料来达到有效止血。这种开发的产品具有高止血活性、生物相容性、生物可吸收性和易于操作性。在具有这些特定要求的外科领域，找到合适的止血剂非常困难。该研究比较了几种具有不同构造特性的材料，通过形态学分析评估了这些材料的结构和相关特性，并使用大鼠肾部分切除术模型在体内评估了它们的效率和行为。具有最低孔隙率和自由溶胀吸收能力的新型羧甲基纤维素 (CMC) 海绵钠盐含有最高量的羟基和羧基。结果表明，这种生物可吸收海绵形式的 CMC 材料可以确保必要的止血效果，同时也对局部组织的反应产生积极影响。CMC 材料还需要明显更少的时间来实现止血（p < 0.001)。此外，海绵在组织病理学评估中达到了令人满意的结果，破坏性评分最低，愈合反应良好。这种改良的产品证明自己是一种很有前途的生物可吸收止血剂，根据其设计，它与其手术应用相匹配。一般来说，获得的数据阐明了总效应对其结构和组成的依赖性。
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