Eight new limonoids, walsogynes H–O (1–8) were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H–M (1–6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c′]difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc:5,4-b′c′]difuran skeleton. Walsogynes H–O (1–8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1 µM, respectively.

Graphic abstract

中文翻译：

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Walsura chrysogyne 的 Walsogynes H-O

八种新的柠檬苦素类化合物 walsogynes H-O ( 1 - 8 ) 是从金黄花的树皮中分离出来的，它们的结构是根据一维和二维核磁共振数据确定的。Walsogynes H–M ( 1 – 6 ) 和 O ( 8 ) 被推断为具有十二氢-1 H-萘并[1,8- bc :3,4- c ']二呋喃骨架的 11,12 - seco柠檬苦素类化合物，并且walsogyne N ( 7 ) 是 11,12- seco柠檬苦素，具有独特的十二氢萘[1,8- bc :5,4- b ' c '] difuran 骨架。Walsogynes H-O ( 1– 8 ) 对恶性疟原虫3D7 菌株表现出有效的抗疟活性，IC ₅₀值分别为 2.5、2.6、1.6、2.5、1.5、2.6、2.1 和 1.1 µM。

图形摘要