Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2021-08-08 , DOI: 10.1007/s00706-021-02821-8 C. P. Kaushik 1 , Manisha Chahal 1
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A series of coumarin appended triazole hybrids of biotic interest was synthesized through click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All the synthesized triazoles were characterized by FT-IR, 1H NMR, 13C NMR, and HRMS and assessed for antimalarial activities against plasmodium falciparum strain. Results revealed that most of the synthesized coumarin–triazole hybrid compounds possess moderate to good activity. Further, the synthesized coumarin triazole hybrids were employed for antioxidant activities and were found to be potent antioxidant when compared with standard drug.
Graphic abstract
中文翻译：
香豆素附加的 1,4-二取代 1,2,3-三唑的合成、抗疟和抗氧化活性
通过点击化学方法从基于香豆素的末端炔烃和芳香叠氮化物合成了一系列具有生物意义的香豆素附加三唑杂化物。所有合成的三唑均通过 FT-IR、1 H NMR、13 C NMR 和 HRMS 进行表征，并评估了对恶性疟原虫菌株的抗疟活性。结果表明，大多数合成的香豆素-三唑杂化化合物具有中等至良好的活性。此外，合成的香豆素三唑杂化物用于抗氧化活性，与标准药物相比，发现它是有效的抗氧化剂。
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