Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2021-08-07 , DOI: 10.1007/s00706-021-02824-5 Debjit Das 1
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An expedient, straightforward, and efficient one-pot three-component synthesis of biologically relevant indole-substituted 4H-chromenes has been developed by the reaction of various indoles, malononitrile, and salicylaldehydes using a catalytic amount of ascorbic acid in aqueous ethanol at room temperature. The significant features of the developed protocol are the clean reaction profile, operational simplicity, non-hazardous experimental conditions, no column chromatographic purification, use of an inexpensive, commercially available, and non-toxic metal-free catalyst, accomplishment of good to excellent yields, and large-scale synthesis.
Graphic abstract
中文翻译：
抗坏血酸：一种有效的有机催化剂，用于吲哚取代的 4H-色烯的环境友好合成
通过各种吲哚、丙二腈和水杨醛的反应，使用催化量的抗坏血酸在乙醇水溶液中室温反应，开发了一种方便、直接且有效的一锅三组分合成生物相关吲哚取代 4 H-色烯温度。所开发的协议的显着特点是干净的反应曲线、操作简单、无危险的实验条件、无柱色谱纯化、使用廉价、市售且无毒的无金属催化剂，实现良好的收率, 和大规模合成。
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