Facile one-pot synthesis of tetrasubstituted N-sulfonylguanidines from sulfonamides and ureas,Monatshefte für Chemie - Chemical Monthly

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Facile one-pot synthesis of tetrasubstituted N-sulfonylguanidines from sulfonamides and ureas
Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2021-08-07 , DOI: 10.1007/s00706-021-02815-6
Fei Wang ₁ , Abudureheman Wusiman _{1,

2} , Abulimiti Yumaier ₂

Affiliation

A facile method for the synthesis of tetrasubstituted N-sulfonylguanidines has been developed via the direct condensation of sulfonamides and ureas in the presence of phosphoryl chloride under basic conditions. Detailed synthetic studies showed that this is a simple protocol for preparing N-sulfonylguanidines at room temperature in a short reaction time with good to excellent yields.