Neuronal aging is associated with numerous diseases resulting in memory impairment and functional decline. A common hallmark of these disorders is the accumulation of intracellular and extracellular protein aggregates. The retromer complex plays a central role in sorting proteins by marking them for reuse rather than degradation. Retromer dysfunction has been shown to induce protein aggregates and neurodegeneration, suggesting that it may be important for age-related neuronal decline and disease progression. Despite this, little is known about how aging influences retromer stability and the proteins with which it interacts. Detailed insights into age-dependent changes in retromer structure and function could provide valuable information towards treating and preventing many age-related neurodegenerative disorders. Here, we visit age-related pathways which interact with retromer function that ought to be further explored to determine its role in age-related neurodegeneration.

神经元衰老与许多导致记忆障碍和功能衰退的疾病有关。这些疾病的一个共同标志是细胞内和细胞外蛋白质聚集体的积累。逆转录酶复合物通过标记蛋白质以供重复使用而不是降解，在分选蛋白质方面发挥着核心作用。逆转录酶功能障碍已被证明可诱导蛋白质聚集和神经变性，这表明它可能对与年龄相关的神经元衰退和疾病进展很重要。尽管如此，人们对衰老如何影响逆转录酶稳定性以及与之相互作用的蛋白质知之甚少。对逆转录结构和功能的年龄依赖性变化的详细见解可以为治疗和预防许多与年龄相关的神经退行性疾病提供有价值的信息。这里，