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A scoping review on the “burned out” or “burnt out” testicular cancer: When a rare phenomenon deserves more attention
Critical Reviews in Oncology/Hematology ( IF 5.5 ) Pub Date : 2021-08-09 , DOI: 10.1016/j.critrevonc.2021.103452
Giovanni Maria Iannantuono 1 , Lidia Strigari 2 , Mario Roselli 1 , Francesco Torino 1
Affiliation  

The “burned out” or “burnt out” testicular cancer (BTC) indicates the spontaneous and complete regression of a testicular germ cell tumor in the presence of distant metastases at the diagnosis. As this condition was never reviewed systematically, a scoping review was conducted to scrutinize the available literature on clinical and histological features of BTC patients. Medline was searched from inception to 19 April 2020. A virtual cohort of 68 BTC patients was generated. Our findings highlighted some inconsistencies: BTC was diagnosed in 5,9% of patients not showing distant metastases and in 2,9% of patients who did not undergo an orchiectomy. Besides, evidence of residual tumor was found in 22,7% of testis specimens, recognized as seminoma in 40% of cases. The emerged inconsistencies may derive from the lack of an unequivocal definition of BTC. Larger collaborative studies are needed to define the best diagnostic workup and treatment for BTC patients.



中文翻译:

关于“精疲力竭”或“精疲力竭”睾丸癌的范围审查:当罕见现象值得更多关注时

“烧坏”或“烧坏”睾丸癌 (BTC) 表明在诊断时存在远处转移的情况下,睾丸生殖细胞肿瘤自发和完全消退。由于从未系统地审查过这种情况,因此进行了范围审查以仔细审查有关 BTC 患者临床和组织学特征的可用文献。从开始到 2020 年 4 月 19 日对 Medline 进行了搜索。生成了 68 名 BTC 患者的虚拟队列。我们的研究结果突出了一些不一致之处:5.9% 的未显示远处转移的患者和 2.9% 的未接受睾丸切除术的患者被诊断为 BTC。此外,在 22.7% 的睾丸标本中发现了残留肿瘤的证据,在 40% 的病例中被认为是精原细胞瘤。出现的不一致可能源于缺乏对 BTC 的明确定义。

更新日期:2021-08-13
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