This case report discusses the clinical signs, diagnostic findings, treatment and outcome for a donkey (Equus asinus) diagnosed with coccidioidomycosis. At presentation, the donkey was lame, was in poor body condition, had a draining tract over the left femur and was hyporexic. Further investigation of the draining tract via radiography and ultrasonography showed a focal lesion of extensive bony proliferation and lysis on the mid-shaft of the left femur. There was also a soft tissue swelling over the fifth left rib. AGID titres were positive for Coccidioides immitis. Recommended treatment for C. immitis consists of two antifungal classes, the azoles and amphotericin B, with this donkey being prescribed daily fluconazole. A recheck 3 months from initial diagnosis showed marked improvement of clinical signs, but the C. immitis titre remained unchanged. The 18-month recheck showed improvement radiographically and significantly decreased titres. After 3 years of daily treatment of fluconazole, the C. immitis titre was decreased, but radiographs of the femur still showed persistent bony proliferation.

中文翻译：

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驴的多灶性球孢子虫（Equus asinus）

本病例报告讨论了一头被诊断为球孢子菌病的驴 ( Equus asinus )的临床症状、诊断结果、治疗和结果。就诊时，这头驴瘸腿，身体状况不佳，左股骨有引流管，并且缺氧。通过放射线照相和超声检查对引流道的进一步调查显示，左侧股骨中轴有广泛的骨质增生和溶解的局灶性病变。左第五肋也有软组织肿胀。AGID滴度对免疫球孢子菌呈阳性。C. immitis的推荐治疗方法由两种抗真菌药物组成，唑类和两性霉素 B，这头驴每天服用氟康唑。初次诊断后 3 个月的复查显示临床症状显着改善，但C. immitis滴度保持不变。18 个月的复查显示影像学有所改善，滴度显着降低。氟康唑每日治疗 3 年后，C. immitis滴度下降，但股骨 X 线片仍显示持续性骨质增生。