Carboplatin, pemetrexed, and pembrolizumab was effective for primary salivary gland-type lung adenocarcinoma diagnosed due to esophageal stricture: A case report,Thoracic Cancer

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Carboplatin, pemetrexed, and pembrolizumab was effective for primary salivary gland-type lung adenocarcinoma diagnosed due to esophageal stricture: A case report
Thoracic Cancer ( IF 2.3 ) Pub Date : 2021-08-08 , DOI: 10.1111/1759-7714.14100
Keita Kawakado _{1,

2} , Tomoki Tamura ₁ , Masamoto Nakanishi ₁ , Go Makimoto ₁ , Yumiko Sato ₃ , Shoichi Kuyama ₁

Affiliation

Primary salivary gland-type tumors of the lung are rare, accounting for <1% of all lung tumors. There are few reports on chemotherapy for the treatment of primary salivary gland-type tumors of the lung. The patient in this report was a 71-year-old woman who presented with a chief complaint of dysphagia. Upper gastrointestinal endoscopy revealed an esophageal stricture, but biopsy showed no malignancy. Chest computed tomography (CT) showed carcinomatous lymphangiomatosis and a nodule in the right lung. Bronchoscopy showed a rough mucous membrane of the central bronchi, while biopsy showed adenocarcinoma. The patient was diagnosed with bronchogenic adenocarcinoma and received carboplatin, pemetrexed, and pembrolizumab, which alleviated the esophageal stricture and cancerous lymphangiopathy. However, the adenocarcinoma progressed, and she subsequently received several rounds of chemotherapy. One year after diagnosis, the patient died, and pathological autopsy revealed primary salivary gland-type tumors of the lung.

中文翻译：

卡铂、培美曲塞和派姆单抗对食管狭窄诊断原发性唾液腺型肺腺癌有效：病例报告

肺原发性唾液腺型肿瘤很少见，占所有肺肿瘤的<1%。很少有关于化疗治疗原发性唾液腺型肺部肿瘤的报道。本报告中的患者是一名 71 岁的女性，主诉吞咽困难。上消化道内镜检查显示食管狭窄，但活检未见恶性肿瘤。胸部计算机断层扫描 (CT) 显示癌性淋巴管瘤病和右肺结节。支气管镜检查显示中央支气管黏膜粗糙，活检显示腺癌。患者被诊断为支气管腺癌，接受了卡铂、培美曲塞和派姆单抗治疗，食管狭窄和癌性淋巴管病得到缓解。然而，腺癌进展，她随后接受了几轮化疗。诊断一年后，患者死亡，病理尸检显示肺部原发性唾液腺型肿瘤。

更新日期：2021-09-17

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