Pectins that Structurally Differ in the Distribution of Methyl-Esters Attenuate Citrobacter rodentium-Induced Colitis,Molecular Nutrition & Food Research

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Pectins that Structurally Differ in the Distribution of Methyl-Esters Attenuate Citrobacter rodentium-Induced Colitis
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-08-09 , DOI: 10.1002/mnfr.202100346
Martin Beukema ₁ , Renate Akkerman ₁ , Éva Jermendi ₂ , Taco Koster ₁ , Anne Laskewitz ₁ , Chunli Kong ₁ , Henk A Schols ₂ , Marijke M Faas ₁ , Paul de Vos ₁

Affiliation

Pectins have anti-inflammatory properties on intestinal immunity through direct interactions on Toll-like receptors (TLRs) in the small intestine or via stimulating microbiota-dependent effects in the large intestine. Both the degree of methyl-esterification (DM) and the distribution of methyl-esters (degree of blockiness; DB) of pectins contribute to this influence on immunity, but whether and how the DB impacts immunity through microbiota-dependent effects in the large intestine is unknown. Therefore, this study tests pectins that structurally differ in DB in a mouse model with Citrobacter rodentium induced colitis and studies the impact on the intestinal microbiota composition and associated attenuation of inflammation.

中文翻译：

甲酯分布结构不同的果胶可减轻啮齿类柠檬酸杆菌引起的结肠炎

果胶通过与小肠中的 Toll 样受体 (TLR) 直接相互作用或通过刺激大肠中的微生物群依赖性作用，对肠道免疫具有抗炎特性。果胶的甲基酯化程度 (DM) 和甲基酯的分布（嵌段度；DB）都会对免疫产生这种影响，但 DB 是否以及如何通过大肠中的微生物群依赖性作用来影响免疫未知。因此，本研究在患有柠檬酸杆菌诱导结肠炎的小鼠模型中测试了 DB 中结构不同的果胶，并研究了其对肠道微生物群组成的影响以及相关的炎症减弱。

更新日期：2021-10-04

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