Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry,European Journal of Organic Chemistry

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Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-08-09 , DOI: 10.1002/ejoc.202100795
Jessica Orrego-Hernández ₁ , Helen Hölzel ₂ , Maria Quant ₂ , Zhihang Wang ₂ , Kasper Moth-Poulsen ₃

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An efficient synthesis of norbornadienes (NBDs) was achieved using flow chemistry via a combination of two reactions in one step. In situ cracking of dicyclopentadiene followed by Diels Alder reaction with alkynes in a flow chemistry setup with back-pressure regulator (BPR) make larger quantities of the norbornadienes (NBD)-quadricyclane (QC) photoswitch pair accessible.

中文翻译：

使用连续流化学通过双环戊二烯的原位裂化可规模化合成降冰片二烯

使用流动化学通过在一个步骤中结合两个反应实现了降冰片二烯 (NBD) 的有效合成。在带有背压调节器 (BPR) 的流动化学装置中，二环戊二烯的原位裂解，然后是与炔烃的 Diels Alder 反应，可以使用大量的降冰片二烯 (NBD)-四环烷 (QC) 光开关对。

更新日期：2021-10-08

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