Recent advances in electrochemical oxidative cross-coupling with hydrogen evolution involving radicals,Chemical Society Reviews

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Recent advances in electrochemical oxidative cross-coupling with hydrogen evolution involving radicals
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-08-09 , DOI: 10.1039/d1cs00150g
Yong Yuan ₁ , Jie Yang ₁ , Aiwen Lei ₂

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Oxidative cross-coupling has developed into a robust method for carbon–carbon (C–C), carbon–heteroatom (C–X), and heteroatom–heteroatom (X–Y) bond formation. Despite considerable advances in this field, the traditional oxidative cross-coupling reactions usually employ stoichiometric amounts of chemical oxidants to clean up surplus electrons from substrates to form new chemical bonds. Organic electrosynthesis is recognized as an environmentally benign and particularly powerful synthetic platform. Recent advancements have revealed that radical-involved electrochemical oxidative cross-coupling reactions can be achieved under exogenous-oxidant-free conditions. This tutorial review provides an overview of the most recent developments in electrochemical oxidative cross-coupling with hydrogen evolution involving radicals. Emphasis is mainly placed on synthetic and mechanistic aspects. We hope that this tutorial review can promote the development of radical chemistry, electrochemistry, and oxidative cross-coupling reactions.

中文翻译：

涉及自由基的析氢电化学氧化交叉偶联的最新进展

氧化交叉偶联已发展成为形成碳-碳 (C-C)、碳-杂原子 (C-X) 和杂原子-杂原子 (X-Y) 键的稳健方法。尽管在该领域取得了相当大的进展，但传统的氧化交叉偶联反应通常使用化学计量的化学氧化剂来清除底物中多余的电子以形成新的化学键。有机电合成被公认为对环境无害且特别强大的合成平台。最近的进展表明，可以在无外源性氧化剂的条件下实现涉及自由基的电化学氧化交叉偶联反应。本教程综述概述了电化学氧化交叉耦合与涉及自由基的析氢的最新进展。重点主要放在合成和机械方面。我们希望本教程综述能够促进自由基化学、电化学和氧化交叉偶联反应的发展。

更新日期：2021-08-09

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