Black phosphorus assisted polyionic micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors,Biomaterials Science

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Black phosphorus assisted polyionic micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-07-26 , DOI: 10.1039/d1bm01033f
Xin Huang ₁ , Yanfei Li ₁ , Dengyu Li ₂ , Xiang Zhou ₁ , Haishi Qiao ₁ , Lifen Yang ₁ , Yicheng Ji ₁ , Xuejiao Zhang ₂ , Dechun Huang _{1,

3} , Wei Chen _{1,

3}

Affiliation

Nanomedicines have been widely used in the effective delivery of chemotherapeutic drugs due to their advantages such as increasing the half-life of drugs, selectively targeting tumor tissues, and thus reducing systemic toxicity. However, the low drug entrapment rate and the difficulty of real-controlled release at tumor sites hinder their further clinical translations. Here we have developed biodegradable polyionic micelles (PD-M) to facilitate black phosphorus (BP) encapsulation (PD-M@BP) for improved drug loading. With the introduction of BP, PTX-loaded PD-M@BP (PD-M@BP/PTX) with sizes of 124–162 nm exhibited superior encapsulation efficiency over 94% and excellent colloidal stability. Meanwhile, PD-M well protected BP from fast degradation to show the good photothermal performance under near-infrared (NIR) irradiation, thus achieving the remotely controlled fast PTX release due to micelle core melting and dissociation, accompanied by the synergistic photothermal tumor therapy. The in vivo results demonstrated that the PD-M@BP/PTX nanosystem not only realized significant inhibition of multi-drug resistant (MDR) cervical tumors (HeLa/PTX^R tumor) by remote NIR-regulation, but also reduced the potential damage of chemotherapeutic drugs to the whole body, rendering these hybrid nanosystems as great tools to treat MDR tumors synergistically.

中文翻译：

具有高效 PTX 负载的黑磷辅助聚离子胶束用于远程控制释放和协同治疗耐药肿瘤

纳米药物因其具有延长药物半衰期、选择性靶向肿瘤组织、降低全身毒性等优点而被广泛应用于化疗药物的有效递送。然而，低药物包封率和在肿瘤部位真正控制释放的困难阻碍了它们进一步的临床转化。在这里，我们开发了可生物降解的聚离子胶束 (PD-M) 以促进黑磷 (BP) 封装 (PD-M@BP) 以改善药物负载。随着BP的引入，尺寸为124-162 nm的PTX负载PD-M@BP（PD-M@BP/PTX）表现出超过94%的优异封装效率和优异的胶体稳定性。同时，PD-M 可以很好地保护 BP 免受快速降解，在近红外 (NIR) 照射下显示出良好的光热性能，从而通过胶束核心熔化和解离实现远程控制的快速 PTX 释放，并伴随协同光热肿瘤治疗。这体内实验结果表明，PD-M@BP/PTX 纳米系统不仅通过远程 NIR 调控实现了对多重耐药（MDR）宫颈肿瘤（HeLa/PTX ^R肿瘤）的显着抑制，而且还降低了化疗药物的潜在损伤。药物应用于全身，使这些混合纳米系统成为协同治疗 MDR 肿瘤的重要工具。

更新日期：2021-08-09

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