A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs?,Journal of Neuroendocrinology

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A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs?
Journal of Neuroendocrinology ( IF 3.3 ) Pub Date : 2021-08-09 , DOI: 10.1111/jne.13025
Fiona Peris-Sampedro ₁ , Marie V Le May ₁ , Iris Stoltenborg ₁ , Erik Schéle ₁ , Suzanne L Dickson ₁

Affiliation

Based on studies delivering ghrelin or ghrelin receptor agonists, we have learned a great deal about the importance of the brain ghrelin signalling system for a wide range of physiological processes that include feeding behaviours, growth hormone secretion and glucose homeostasis. Because these processes can be considered as essential to life, the question arises as to why mouse models of depleted ghrelin signalling are not all skinny dwarfs with a host of behavioural and metabolic problems. Here, we provide a systematic detailed review of the phenotype of mice with deficient ghrelin signalling to help better understand the relevance and importance of the brain ghrelin signalling system, with a particular emphasis on those questions that remain unanswered.

中文翻译：

ghrelin 研究中橱柜里的骷髅：瘦矮人在哪里？

基于提供 ghrelin 或 ghrelin 受体激动剂的研究，我们已经了解到大脑 ghrelin 信号系统对于包括摄食行为、生长激素分泌和葡萄糖稳态在内的广泛生理过程的重要性。因为这些过程可以被认为是生命所必需的，所以出现了一个问题，即为什么耗尽的生长素释放肽信号的小鼠模型并不都是具有许多行为和代谢问题的瘦小矮人。在这里，我们对缺乏 ghrelin 信号传导的小鼠的表型进行了系统的详细回顾，以帮助更好地了解大脑 ghrelin 信号传导系统的相关性和重要性，特别强调那些仍未得到解答的问题。

更新日期：2021-08-09

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