• Critical limb ischemia (CLI) patients with end-stage renal disease (ESRD) undergoing endovascular or open revascularization have 50%–70% lower odds of survival, freedom from amputation, and secondary patency than those without ESRD.
• Increased arterial medial calcification, inflammation, comorbidities, and impaired wound healing are the likely causes of worse outcomes in ESRD CLI patients after revascularization compared to other CLI patients without ESRD.
• Better risk prediction to inform revascularization decisions and enhanced local wound care are potential avenues for improving outcomes awaiting development of more effective systemic therapies and revascularization approaches for ESRD CLI patients.

中文翻译：

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终末期肾病患者的严重肢体缺血：接下来的一些步骤

• 接受血管内或开放性血运重建术的终末期肾病 (ESRD) 危重肢体缺血 (CLI) 患者的生存率、免截肢率和继发性通畅率比没有 ESRD 的患者低 50%–70%。
• 与其他无 ESRD 的 CLI 患者相比，血管重建后 ESRD CLI 患者的动脉内侧钙化增加、炎症、合并症和伤口愈合受损可能是导致预后更差的原因。
• 更好的风险预测以告知血运重建决策和加强局部伤口护理是改善结果的潜在途径，等待为 ESRD CLI 患者开发更有效的全身疗法和血运重建方法。