Research question

Is the growth of term singletons born after frozen embryo transfer (FET) comparable to those born after fresh embryo transfer and natural conception up to 5 years of age?

Design

Observational cohort study in an academic medical centre and municipal child health clinics with repeated measurements carried out by medical professionals. Term singletons born after FET (n = 110) and fresh embryo transfer (n = 181) and their matched natural conception controls (n = 543) born in Oulu, Northern Finland, were included. Mean weights, lengths, heights and head circumferences at the ages of 4, 8 and 18 months and 3 and 5 years were compared. At 3 and 5 years, body mass indices were compared.

Results

Childhood growth did not differ between term singletons born after FET, fresh embryo transfer and natural conception, correcting for exact age at measurement and adjusting for maternal body mass index and paternal height.

Conclusions

Similar growth between children born after FET, fresh embryo transfer and natural conception offers reassurance of the safety and feasibility of the steadily increasing use of embryo cryopreservation in assisted reproduction.

中文翻译：

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与新鲜胚胎移植相比，冷冻后出生的足月单胎的儿童成长

研究问题

冷冻胚胎移植 (FET) 后出生的足月单胎的生长是否与新鲜胚胎移植和自然受孕后出生至 5 岁的婴儿相当？

设计

在学术医疗中心和市政儿童健康诊所进行的观察性队列研究，由医疗专业人员进行重复测量。 包括在芬兰北部奥卢出生的FET ( n  = 110) 和新鲜胚胎移植 ( n  = 181) 后出生的足月单胎及其匹配的自然受孕对照 ( n = 543)。比较了 4、8 和 18 个月以及 3 和 5 岁时的平均体重、长度、身高和头围。在 3 年和 5 年时，比较了体重指数。

结果

在 FET、新鲜胚胎移植和自然受孕后出生的足月单胎之间，儿童生长没有差异，校正了测量时的确切年龄，并调整了母亲体重指数和父亲身高。

结论

在 FET、新鲜胚胎移植和自然受孕后出生的孩子之间的相似生长为胚胎冷冻保存在辅助生殖中稳步增加使用的安全性和可行性提供了保证。