Abstract

A MoS₂ nanosheets drug delivery system with photothermal conversion ability was synthesized. The drug loading content of the synthesized was as high as 24.5%. The drug HCPT was modified by lipoic acid (LA) and connected onto MoS₂ nanosheets through S-Mo bond, which is more stable than physical adsorption. Due to the ester bond between HCPT and MoS₂ nanosheets, the drug delivery system could responsively release HCPT when exposed to esterase.

中文翻译：

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二硫化钼纳米片给药系统的合成及其药物释放行为

摘要

合成了具有光热转换能力的MoS ₂纳米片给药系统。合成的载药量高达24.5%。药物HCPT经硫辛酸(LA)修饰，通过S-Mo键连接到MoS ₂纳米片上，比物理吸附更稳定。由于HCPT 和MoS ₂纳米片之间的酯键，当暴露于酯酶时，药物递送系统可以响应地释放HCPT。