Acetylcholinesterase Biosensor Based on Reduced Graphene Oxide – Carbon Black Composite for Determination of Reversible Inhibitors,Electroanalysis

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Acetylcholinesterase Biosensor Based on Reduced Graphene Oxide – Carbon Black Composite for Determination of Reversible Inhibitors
Electroanalysis ( IF 2.7 ) Pub Date : 2021-08-08 , DOI: 10.1002/elan.202100385
Rezeda Shamagsumova ₁ , Alexey Rogov ₁ , Dmitry Shurpik ₂ , Ivan Stoikov ₃ , Gennady Evtugyn ₁

Affiliation

For the first time, acetylcholinesterase (AChE) biosensors based on mixed carbon nanomaterials (electrochemically reduced graphene oxide (ERGO) and carbon black (CB) particles) were described for the determination of antidementia drugs. Changes in the content of underlying layer allowed varying selectivity and sensitivity of the inhibitor determination. Appropriate limits of detection (LOD) varied in the range from 1 pM to 0.1 nM for donepezil, 5 nM–0.1 μM for berberine, 0.1–50 nM for huperzine A and 0.1–300 nM for galantamine. Variation in the inhibition measurement parameters can be used for increasing selectivity of the measurements.

中文翻译：

基于还原氧化石墨烯-炭黑复合物的乙酰胆碱酯酶生物传感器用于可逆抑制剂的测定

首次描述了基于混合碳纳米材料（电化学还原氧化石墨烯 (ERGO) 和炭黑 (CB) 颗粒）的乙酰胆碱酯酶 (AChE) 生物传感器，用于测定抗痴呆药物。底层含量的变化允许抑制剂测定的选择性和灵敏度发生变化。多奈哌齐的适当检测限 (LOD) 在 1 pM 至 0.1 nM 范围内变化，黄连素为 5 nM–0.1 μM，石杉碱 A 为 0.1–50 nM，加兰他敏为 0.1–300 nM。抑制测量参数的变化可用于增加测量的选择性。

更新日期：2021-08-08

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