Fully continuous drying can improve the production flexibility and throughput of tablets manufactured by wet granulation lines. A recently developed prototype incorporates a screw conveyor to a horizontal fluidized bed dryer for pharmaceutical particles. Research on advanced process control strategies led to the publication of a two-phase tanks-in-series framework to describe its dynamics. This paper calibrates the model to replicate the prototype behavior. A grey-box identification methodology estimates the empirical and uncertain parameters using experimental input-output data. The underlying assumptions are cross-validated with time-domain comparisons, output root mean square errors and confidence intervals. Results show that the model reproduces the observed trends in general and the discrepancies result from mechanical issues on the equipment.

完全连续干燥可以提高湿法制粒线生产的片剂的生产灵活性和产量。最近开发的原型将螺旋输送机与用于药物颗粒的卧式流化床干燥机相结合。对先进过程控制策略的研究导致发布了一个两相串联罐框架来描述其动力学。本文校准模型以复制原型行为。灰盒识别方法使用实验输入输出数据来估计经验和不确定参数。基本假设通过时域比较、输出均方根误差和置信区间进行交叉验证。结果表明，该模型总体上再现了观察到的趋势，而差异是由设备上的机械问题引起的。