Microbial community in human gut: a therapeutic prospect and implication in health and diseases,Letters in Applied Microbiology

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Microbial community in human gut: a therapeutic prospect and implication in health and diseases
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2021-08-08 , DOI: 10.1111/lam.13549
M Dwivedi ₁ , S Powali ₂ , S Rastogi ₁ , A Singh ₁ , D K Gupta ₃

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The interest in the working and functionality of the human gut microbiome has increased drastically over the years. Though the existence of gut microbes has long been speculated for long over the last few decades, a lot of research has sprung up in studying and understanding the role of gut microbes in the human digestive tract. The microbes present in the gut are highly instrumental in maintaining the metabolism in the body. Further research is going on in this field to understand how gut microbes can be employed as potential sources of novel therapeutics; moreover, probiotics have also elucidated their significant place in this direction. As regards the clinical perspective, microbes can be engineered to afford defence mechanisms while interacting with foreign pathogenic bodies. More investigations in this field may assist us to evaluate and understand how these cells communicate with human cells and promote immune interactions. Here we elaborate on the possible implication of human gut microbiota into the immune system as well as explore the probiotics in the various human ailments. Comprehensive information on the human gut microbiome at the same platform may contribute effectively to our understanding of the human microbiome and possible mechanisms of associated human diseases.

中文翻译：

人体肠道微生物群落：健康和疾病的治疗前景和意义

多年来，人们对人体肠道微生物组的工作和功能的兴趣急剧增加。尽管在过去的几十年里，人们长期以来一直推测肠道微生物的存在，但在研究和理解肠道微生物在人类消化道中的作用方面，涌现了大量研究。肠道中存在的微生物在维持体内新陈代谢方面非常重要。该领域正在进行进一步的研究，以了解如何利用肠道微生物作为新疗法的潜在来源；此外，益生菌也阐明了它们在这个方向上的重要地位。从临床角度来看，微生物可以被设计成在与外来病原体相互作用的同时提供防御机制。该领域的更多研究可能有助于我们评估和了解这些细胞如何与人体细胞交流并促进免疫相互作用。在这里，我们详细阐述了人类肠道微生物群对免疫系统的可能影响，并探索了各种人类疾病中的益生菌。在同一平台上有关人类肠道微生物组的综合信息可能有助于我们了解人类微生物组和相关人类疾病的可能机制。

更新日期：2021-08-08

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