ABSTRACT

Inflammatory bowel disease (IBD) is a critical disorder characterized by chronic inflammation of the gastrointestinal tract, primarily the small intestine and colon, which eventually leads to disruption of the gut barrier function. Panax ginseng (P. ginseng) is an important traditional herb, which contains various active constituents known as ginsenosides. Ginsenoside Rf (Rf) is a dynamic component of P. ginseng and is rarely available in other species. This study determined the anti-inflammatory effects of Rf in a dextran sodium sulfate (DSS)-induced colitis mouse model. The results demonstrated significantly lower body weight loss and shortening of colon length in mice treated with Rf than in DSS-treated mice. In addition, inflammatory signalling mechanisms involving interleukin-6 and tumour necrosis factor-alpha were inhibited in Rf-treated mice. The results suggest Rf as a potential anti-inflammatory agent that can be used for the treatment of IBD.

摘要

炎症性肠病 (IBD) 是一种以胃肠道慢性炎症为特征的严重疾病，主要是小肠和结肠，最终导致肠道屏障功能的破坏。人参（P. ginseng）是一种重要的传统草药，含有多种活性成分，称为人参皂苷。Ginsenoside Rf (Rf) 是P. ginseng的动态成分并且在其他物种中很少可用。本研究确定了 Rf 在葡聚糖硫酸钠 (DSS) 诱导的结肠炎小鼠模型中的抗炎作用。结果表明，与 DSS 治疗的小鼠相比，用 Rf 治疗的小鼠的体重减轻和结肠长度缩短显着降低。此外，涉及白细胞介素-6 和肿瘤坏死因子-α 的炎症信号机制在 Rf 治疗的小鼠中受到抑制。结果表明 Rf 是一种潜在的抗炎剂，可用于治疗 IBD。