ABSTRACT

Dry eye disease (DED), a multifactorial condition of the tear film and ocular surface, is one of the leading reasons for patients seeking eye care. Despite the multiple toxic ingredients of eye make-up products and their long-term application close to the ocular surface, few studies have analyzed their role in initiating and worsening DED. Females and the elderly experience the highest prevalence of DED and may be particularly vulnerable to the effects of eye make-up. The multifactorial nature of DED and common mechanisms behind several ocular surface diseases make it difficult to link a particular ingredient-driven mechanism to DED. Therefore, here, we list potential responses to eye cosmetics that may be involved in DED development. The first part of this review introduces the anatomy of the eye and DED, the second section explains the classification of eye cosmetic products, and the final part discusses the undesired effects under physical, pathogenic, and chemical insults.

摘要

干眼病 (DED) 是泪膜和眼表的多因素疾病，是患者寻求眼部护理的主要原因之一。尽管眼部化妆品含有多种有毒成分，并且它们在眼表附近长期使用，但很少有研究分析它们在引发和恶化 DED 中的作用。女性和老年人的 DED 患病率最高，并且可能特别容易受到眼部化妆的影响。DED 的多因素性质和几种眼表疾病背后的共同机制使得很难将特定成分驱动的机制与 DED 联系起来。因此，在这里，我们列出了可能参与 DED 开发的眼部化妆品的潜在反应。这篇评论的第一部分介绍了眼睛的解剖结构和 DED，