In this report, a series of chalcone-benzoxadiazole hybrids; 3a–3g were synthesized by substituting in phenyl ring C_4′ with –OCH₃, -CH₃, -F, -Cl, -Br and C_3′ with -NO₂. Anticancer potential of 3a–3g on KB human cancer cell line was evaluated by using MTT assay. The order of anticancer activity of derived hybrids with phenyl ring substitution is, p–OCH₃, p-F, p-Br> parent hybrid,p-Cl,m-NO₂,>p-CH₃.Among them, hybrids with p–OCH₃, p-F, p-Br exhibited strong antiproliferation effect (IC₅₀ = 15 µM) exhibitshighest anticancer behavior. The reported haptophoric hybrids may provide a useful insight for designing effective chemotherapy drugs for treating KB cancer cells.

在本报告中，一系列查耳酮-苯并恶二唑杂化物； 图3a-3克通过在苯基环C取代合成_'4与-OCH ₃，-CH ₃，-F，-Cl，-Br和C _3'与-NO ₂。使用 MTT 测定法评估3a- 3g对 KB 人癌细胞系的抗癌潜力。苯环取代的衍生杂合体的抗癌活性顺序为，p- OCH ₃ ，p- F，p- Br>亲本杂合体，p- Cl，m- NO ₂，> p -CH ₃.其中，具有p -OCH ₃ 、p -F 、p- Br 的杂种表现出强烈的抗增殖作用（IC ₅₀  = 15 µM），表现出最高的抗癌行为。报道的触觉杂种可能为设计用于治疗 KB 癌细胞的有效化疗药物提供有用的见解。