Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis initially promotes memory deficits, behavioral changes, and epileptic seizures. We developed a new animal model of anti-NMDAR encephalitis using a single cerebroventricular injection of CSF from patients in adult zebrafish. We observed a reduction of the seizure threshold and recent memory deficits in those animals injected with CSF from patients with anti-NMDAR encephalitis. The locomotor activity was similar in the CSF and control groups. This zebrafish model consistently recapitulates symptoms seen in patients with anti-NMDAR encephalitis. It may provide a reliable, fast and cost-effective platform to investigate new therapeutic strategies to anti-NMDAR encephalitis.

抗Ñ甲基d天冬氨酸受体（抗NMDAR）脑炎最初促进记忆缺失，行为变化，和癫痫发作。我们使用来自成年斑马鱼患者的单次脑室注射 CSF 开发了一种新的抗 NMDAR 脑炎动物模型。我们观察到注射了来自抗 NMDAR 脑炎患者的 CSF 的那些动物的癫痫发作阈值和近期记忆缺陷降低。脑脊液和对照组的运动活动相似。这种斑马鱼模型始终如一地概括了抗 NMDAR 脑炎患者的症状。它可以为研究抗 NMDAR 脑炎的新治疗策略提供一个可靠、快速和具有成本效益的平台。