A new palladium(II) complex entitled [Pd(phendione)(8Q)]NO₃, (PdPQ), where phendione is N,N-donor heterocyclic 1,10-phenanthroline-5,6-dion and 8Q is 8-hydroxyquinolinate, has been synthesized and then characterized by molar conductivity, CHN analysis and spectral data (UV–Vis, FT-IR, NMR). DFT/ TDDFT procedures were also performed to determine the electronic structure and the nature of the electronic transitions of PdPQ. Moreover, the affinity and binding properties of DNA to the desired complex have been studied in details using electronic absorption, fluorescence, circular dichroism spectroscopies, and viscosity measurement in combination with molecular docking technique. The obtained results exhibit relatively high DNA binding values with a static quenching mechanism, which suggest that an intercalative mode plays a peridominate role in interaction process concluded by experimental/theoretical measurements. As a result of drug exposure, in vitro cytotoxicity assay demonstrated the antiproliferative activity of the PdPQ against leukemia cancer cell line, K562.

一种名为[Pd(phendione)(8Q)]NO _{3的新型钯(II)配合物}, (PdPQ)，其中苯二酮是 N,N-供体杂环 1,10-phenanthroline-5,6-dion，8Q 是 8-羟基喹啉，已合成，然后通过摩尔电导率、CHN 分析和光谱数据（UV-可见光、红外光谱、核磁共振）。还进行了 DFT/TDDFT 程序以确定 PdPQ 的电子结构和电子跃迁的性质。此外，已经使用电子吸收、荧光、圆二色光谱和粘度测量结合分子对接技术详细研究了 DNA 对所需复合物的亲和力和结合特性。获得的结果显示出相对较高的 DNA 结合值，具有静态猝灭机制，这表明插层模式在通过实验/理论测量得出的相互作用过程中起着主导作用。由于药物暴露，体外细胞毒性试验证明了 PdPQ 对白血病癌细胞系 K562 的抗增殖活性。