The development of treatments for systemic sclerosis has historically been hampered by the clinical heterogeneity of the disease and limited understanding of its pathogenesis. Encouragingly, advances including the identification of important molecular targets and improvements in clinical trial design have now greatly increased the number of investigative therapies.

中文翻译：

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系统性硬化症治疗的前景和挑战

系统性硬化症治疗的发展历来受到疾病的临床异质性和对其发病机制的有限了解的阻碍。令人鼓舞的是，包括重要分子靶点的识别和临床试验设计的改进在内的进步现在大大增加了研究性疗法的数量。