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DABCO-Promoted [3+2] Annulation for Efficient Synthesis of 1,2,5-Triaryl-1H-imidazoles from Substituted β-Nitrostyrenes and N-Arylbenzimidamides
Synthesis ( IF 2.2 ) Pub Date : 2021-06-22 , DOI: 10.1055/a-1533-6872
Cunde Wang , Yue Zhang , Xinyi Wan , Jianbo Gan

An efficient approach to the synthesis of 1,2,5-trisubstituted imidazole derivatives was investigated via a DABCO-promoted formal [3+2]-annulation reaction of substituted N-arylbenzimidamides and substituted β-nitrostyrenes. The annulation reaction is implemented easily to afford the corresponding products in moderate to good yields with excellent regioselectivity.

中文翻译:

DABCO 促进的 [3+2] 环化用于从取代的 β-硝基苯乙烯和 N-芳基苯甲酰胺有效合成 1,2,5-三芳基-1H-咪唑

通过 DABCO 促进的取代 N-芳基苯甲酰胺和取代 β-硝基苯乙烯的正式 [3+2]-环化反应,研究了一种合成 1,2,5-三取代咪唑衍生物的有效方法。环化反应很容易实现,以中等至良好的收率和优异的区域选择性提供相应的产物。
更新日期:2021-08-07
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