Transcriptional repression shapes the identity and function of tissue macrophages,FEBS Open Bio

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Transcriptional repression shapes the identity and function of tissue macrophages
FEBS Open Bio ( IF 2.8 ) Pub Date : 2021-08-06 , DOI: 10.1002/2211-5463.13269
Krisztian Bene ₁ , Laszlo Halasz ₂ , Laszlo Nagy _{1,

2}

Affiliation

The changing extra- and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level. The cellular components of the immune system are excellent examples of how cells respond and adapt to different environmental stimuli. Innate immune cells such as macrophages are able to modulate their transcriptional programs and epigenetic regulatory networks through activation and repression of particular genes, allowing them to quickly respond to a rapidly changing environment. Tissue macrophages are essential components of different immune- and nonimmune cell-mediated physiological mechanisms in mammals and are widely used models for investigating transcriptional regulatory mechanisms. Therefore, it is critical to unravel the distinct sets of transcription activators, repressors, and coregulators that play roles in determining tissue macrophage identity and functions during homeostasis, as well as in diseases affecting large human populations, such as metabolic syndromes, immune-deficiencies, and tumor development. In this review, we will focus on transcriptional repressors that play roles in tissue macrophage development and function under physiological conditions.

中文翻译：

转录抑制塑造了组织巨噬细胞的特性和功能

不断变化的细胞外和细胞内微环境需要快速的细胞命运决定，这些决定在转录水平上受到精确且主要的调节。免疫系统的细胞成分是细胞如何响应和适应不同环境刺激的极好例子。巨噬细胞等先天免疫细胞能够通过激活和抑制特定基因来调节其转录程序和表观遗传调控网络，从而使它们能够快速响应快速变化的环境。组织巨噬细胞是哺乳动物中不同免疫和非免疫细胞介导的生理机制的重要组成部分，是研究转录调控机制的广泛使用的模型。因此，解开不同的转录激活因子、阻遏因子、和共同调节因子，它们在确定体内平衡期间的组织巨噬细胞特性和功能以及影响大量人群的疾病中发挥作用，例如代谢综合征、免疫缺陷和肿瘤发展。在这篇综述中，我们将重点关注在生理条件下在组织巨噬细胞发育和功能中发挥作用的转录抑制因子。

更新日期：2021-08-06

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