The host immune system plays a crucial role in multiple types of cancer, including non-small-cell lung cancer (NSCLC). Transporter associated with antigen processing (TAP) protein heterodimer complexes might promote intracellular antigen peptide binding with class I major histocompatibility complex (MHC-I) molecules, and in recent years, TAP1 and TAP2 have been reported to be associated with multiple cancer risks. In the current study, we investigated the association of single-nucleotide polymorphisms (SNPs) in TAP1 and TAP2 with NSCLC in a Han Chinese population. Six and seven TAP1 and TAP2 SNPs, respectively, were genotyped and analysed in healthy controls and NSCLC patients. Based on our data, none of the six SNPs in TAP1 is associated with NSCLC risk (P > 0.0038). However, rs2228396 alleles in TAP2 were significantly different between NSCLC patients and healthy controls, and the A allele might be associated with an increased risk of this cancer (P = 0.001, OR = 1.65, 95%CI: 1.23 ∼ 2.21). Moreover, the genotype frequencies of rs2228396 were significantly different between patients and healthy controls (P = 7 × 10⁻⁴). Additionally, TAP2 rs241441 alleles exhibited a trend of difference between NSCLC patients and healthy controls, with the C allele possibly being associated with increased risk of NSCLC (P = 0.013; OR = 1.30, 95%CI: 1.06 ∼ 1.60). Moreover, the genotypes of rs241441 in TAP2 showed a significant difference between NSCLC patients and healthy controls (P = 1 × 10⁻⁴). In haplotype analysis, the TAP2 SNP haplotype (CAC, TAP2*0102) was significantly associated with increased NSCLC risk in the Han Chinese population (P = 0.003; OR = 1.57, 95%CI: 1.17 ∼ 2.10). Our results indicate that TAP2 SNPs (rs2228396 and rs241441) have a potential role in NSCLC pathogenesis.

宿主免疫系统在包括非小细胞肺癌 (NSCLC) 在内的多种癌症中发挥着至关重要的作用。与抗原加工 (TAP) 蛋白异二聚体复合物相关的转运蛋白可能促进细胞内抗原肽与 I 类主要组织相容性复合物 (MHC-I) 分子结合，近年来，据报道TAP1和TAP2与多种癌症风险相关。在目前的研究中，我们调查了汉族人群中TAP1和TAP2中的单核苷酸多态性 (SNP)与 NSCLC 的关联。六七TAP1和TAP2分别在健康对照和 NSCLC 患者中对 SNP 进行基因分型和分析。根据我们的数据，TAP1中的六个 SNP 中没有一个与 NSCLC 风险相关（P  > 0.0038）。然而，TAP2中的 rs2228396 等位基因在 NSCLC 患者和健康对照之间存在显着差异，A 等位基因可能与这种癌症的风险增加有关（P  = 0.001，OR = 1.65，95%CI：1.23 ∼ 2.21）。此外，rs2228396 的基因型频率在患者和健康对照之间存在显着差异（P  = 7 × 10 ^-4）。此外，TAP2rs241441等位基因在NSCLC患者和健康对照之间表现出差异趋势，C等位基因可能与NSCLC风险增加有关（P  =0.013；OR=1.30，95%CI：1.06～1.60）。此外， TAP2中 rs241441 的基因型在 NSCLC 患者和健康对照之间显示出显着差异（P  = 1 × 10 ^-4）。在单倍型分析中，TAP2 SNP 单倍型（CAC，TAP2*0102）与汉族人群 NSCLC 风险增加显着相关（P  = 0.003；OR = 1.57，95%CI：1.17 ∼ 2.10）。我们的结果表明TAP2 SNP（rs2228396 和 rs241441）在 NSCLC 发病机制中具有潜在作用。