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Structure and function of the ventricular tachycardia isthmus
Heart Rhythm ( IF 5.6 ) Pub Date : 2021-08-06 , DOI: 10.1016/j.hrthm.2021.08.001
Edward J Ciaccio 1 , Elad Anter 2 , James Coromilas 3 , Elaine Y Wan 4 , Hirad Yarmohammadi 4 , Andrew L Wit 5 , Nicholas S Peters 6 , Hasan Garan 4
Affiliation  

Catheter ablation of postinfarction reentrant ventricular tachycardia (VT) has received renewed interest owing to the increased availability of high-resolution electroanatomic mapping systems that can describe the VT circuits in greater detail, and the emergence and need to target noninvasive external beam radioablation. These recent advancements provide optimism for improving the clinical outcome of VT ablation in patients with postinfarction and potentially other scar-related VTs. The combination of analyses gleaned from studies in swine and canine models of postinfarction reentrant VT, and in human studies, suggests the existence of common electroanatomic properties for reentrant VT circuits. Characterizing these properties may be useful for increasing the specificity of substrate mapping techniques and for noninvasive identification to guide ablation. Herein, we describe properties of reentrant VT circuits that may assist in elucidating the mechanisms of onset and maintenance, as well as a means to localize and delineate optimal catheter ablation targets.



中文翻译:


室性心动过速峡部的结构和功能



由于可以更详细地描述 VT 回路的高分辨率电解剖测绘系统的可用性增加,以及针对无创外束放射消融的出现和需求,梗死后折返性室性心动过速 (VT) 的导管消融重新引起了人们的兴趣。这些最新进展为改善梗塞后和其他可能与疤痕相关的室速患者室速消融的临床结果带来了乐观的前景。对梗死后折返性 VT 的猪和犬模型的研究以及人类研究中收集的分析相结合,表明折返性 VT 回路存在常见的电解剖特性。表征这些特性可能有助于提高基质测绘技术的特异性以及指导消融的非侵入性识别。在此,我们描述了折返性 VT 回路的特性,这些特性可能有助于阐明起始和维持的机制,以及定位和描绘最佳导管消融目标的方法。

更新日期:2021-08-06
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