Gastrointestinal stromal tumors (GISTs) are the stromal or mesenchymal neoplasms affecting the gastrointestinal tract. Although they constitute 1% of primary gastrointestinal tumors, they are the most common nonepithelial tumors involving the gastrointestinal tract. They mostly present as overt or occult gastrointestinal bleeding. We present a case in which a 77-year-old female presented with a large abdominal mass. The origin of the mass was unclear on CT and MRI scan of the abdomen. Upper gastrointestinal endoscopic ultrasonography showed a cystic lesion in the perigastric region. A fine-needle biopsy of the lesion was performed, which was consistent with spindle type GIST. After the initial failure of imatinib therapy, the tumor was managed surgically.
Case Rep Gastroenterol 2021;15:736–741

中文翻译：

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伊马替尼耐药的胃肠道间质瘤表现为腹部大肿块

胃肠道间质瘤 (GIST) 是影响胃肠道的间质或间充质肿瘤。虽然它们占原发性胃肠道肿瘤的 1%，但它们是最常见的胃肠道非上皮肿瘤。它们大多表现为明显或隐匿的胃肠道出血。我们提出了一个案例，其中一名 77 岁的女性出现了一个巨大的腹部肿块。腹部 CT 和 MRI 扫描显示肿块来源不明。上消化道内镜超声检查显示胃周区域有囊性病变。对病变进行了细针活检，结果与纺锤体型 GIST 一致。在伊马替尼治疗最初失败后，肿瘤被手术治疗。
Case Rep Gastroenterol 2021；15:736–741