Cohort studies of patients with pectus excavatum have inadequately characterised exercise dysfunction experienced. Cardiopulmonary exercise test data were delineated by maximal oxygen uptake values >80%, which was tested to examine whether patterns of exercise physiology were distinguished. Methods Seventy-two patients considered for surgical treatment underwent assessment of pulmonary function and exercise physiology with pulmonary function tests and cardiopulmonary exercise test between 2006 and 2019. Seventy who achieved a threshold respiratory gas exchange ratio of >1.1 were delineated by maximal oxygen uptake >80%, (group A, n=33) and <80% (group B, n=37) and comparison of constituent physiological parameters performed. Results The cohort was 20.8 (±SD 6.6) years of age, 60 men, with a Haller’s Index of 4.1 (±SD 1.4). Groups A and B exhibited similar demography, pulmonary function test results and Haller’s index values. Exercise test parameters of group B were lower than group A; work 79.2% (±SD 11.3) versus 97.7 (±SD 10.1), anaerobic threshold 38.1% (±SD 7.8) versus 49.7% (±SD 9.1) and O2 pulse 77.4% (±SD 9.8) versus 101.8% (±SD 11.7), but breathing reserve was higher, 54.9% (±SD 13.1) versus 44.2% (±SD 10.8), p<0.001 for each. Both groups exhibited similar incidences of carbon dioxide retention at peak exercise. A total of 65 (93%) exhibited abnormal values of at least one of four exercise test measures. Conclusion This study showed that patients with pectus excavatum exhibited multiple physiological characteristics of compromised exercise function. It is the first study that defines differing patterns of exercise dysfunction and provides evidence that patients with symptomatic pectus excavatum should be considered for surgical treatment. Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information.

中文翻译：

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最大摄氧量的分类值能否区分漏斗胸运动功能障碍的模式：一项前瞻性队列研究？


对漏斗胸患者进行的队列研究尚未充分描述所经历的运动功能障碍。心肺运动测试数据以最大摄氧量>80%描绘，通过测试来检查运动生理学模式是否被区分。方法 2006 年至 2019 年间，72 名考虑接受手术治疗的患者通过肺功能测试和心肺运动测试进行了肺功能和运动生理学评估。其中 70 名达到阈值呼吸气体交换率 >1.1 的患者通过最大摄氧量进行描述>80%（A 组，n=33）和 <80%（B 组，n=37）并进行组成生理参数的比较。结果 该队列由 60 名男性组成，年龄 20.8 (±SD 6.6)，Haller 指数为 4.1 (±SD 1.4)。 A 组和 B 组表现出相似的人口统计学、肺功能测试结果和 Haller 指数值。 B组运动试验参数低于A组；做功 79.2% (±SD 11.3) 对比 97.7 (±SD 10.1)，无氧阈值 38.1% (±SD 7.8) 对比 49.7% (±SD 9.1)，O2 脉冲 77.4% (±SD 9.8) 对比 101.8% (±SD 11.7) ），但呼吸储备更高，分别为 54.9% (±SD 13.1) 和 44.2% (±SD 10.8)，p<0.001。两组在运动高峰时二氧化碳潴留的发生率相似。共有 65 名受试者 (93%) 在四项运动测试指标中至少一项表现出异常值。结论 本研究表明漏斗胸患者表现出运动功能受损的多种生理特征。这是第一项定义不同运动功能障碍模式的研究，并提供证据表明有症状的漏斗胸患者应考虑接受手术治疗。 数据可根据合理要求提供。与研究相关的所有数据都包含在文章中或作为补充信息上传。