ABSTRACT

Background

Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out.

Objectives

To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders.

Methods

Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc.

Results

It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases.

Conclusion

Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.

中文翻译：

---

当前证据支持黄酮类化合物在氧化应激相关皮肤病中的治疗潜力

摘要

背景

皮肤作为重要的外部防御器官，更容易受到氧化应激 (OS) 的伤害，尤其是活性氧 (ROS) 介导的 OS。OS 是由各种外在刺激引起的氧化还原失衡引起的，一旦产生的氧化剂超过了抗氧化剂的能力就会发生，通过介导 DNA 损伤、脂质过氧化 (LPO)、蛋白质氧化和一系列信号通路的激活/失活，从而提供有利条件用于多种疾病的发生发展，尤其是一些皮肤病，如银屑病、白斑、皮肤光损伤、皮肤癌、系统性硬化症（SSc）、黄褐斑、特应性皮炎（AD）、天疱疮等。 针对OS分子机制，多种抗-OS 剂出现，其中类黄酮、天然植物提取物脱颖而出。

目标

讨论OS介导皮肤病的可能机制，总结黄酮类化合物的特性及其在OS相关皮肤病中的应用。

方法

通过在 PubMed、MEDLINE 和 Embase 等上的数据库搜索，收集和审查有关黄酮类化合物和 OS 相关皮肤病的已发表论文。

结果

已经证实，黄酮类化合物属于多酚类物质，是一类广泛分布于各种植物中的植物次生代谢产物，具有多种生物活性，尤其是其强大的抗氧化能力。此外，黄酮类化合物通过清除自由基和介导相应信号来抑制 OS，在 OS 相关皮肤病的预防和管理中进一步发挥出色作用。

结论

类黄酮对氧化应激相关的皮肤病具有潜在的治疗作用。然而，未来需要对具体机制以及黄酮类化合物的剂量进行更多研究。