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Gold(III)-catalyzed synthesis of 2,5-disubstituted furans from substituted 5-methoxyhex-3-yn-2-ols—Mechanistic outlook
Synthetic Communications ( IF 1.8 ) Pub Date : 2021-08-06 , DOI: 10.1080/00397911.2021.1961274
Sagarika Behera 1 , Nabakumar Bera 1 , Debayan Sarkar 1
Affiliation  

Abstract

Gold(III)-catalyzed activation of alkynes has been applied for the synthesis of 2,5-disubstituted furans from substituted 5-methoxy-hex-3-yn-2-ols. Mechanistically, the reaction proceeds via an allenyl carbocation intermediate followed by 5-endo-dig cyclization. The high-yielding, open-air, room temperature reaction conditions applied to synthesize a series of alkyl, aryl, and hetero aryl-substituted furans provide uniqueness to the strategy.



中文翻译:

金(III)催化从取代的5-甲氧基己基-3-yn-2-醇合成2,5-二取代呋喃——机理展望

摘要

金 (III) 催化的炔烃活化已被用于从取代的 5-甲氧基-己基-3-yn-2-醇合成 2,5-二取代呋喃。从机制上讲,该反应通过烯丙基碳正离子中间体进行,然后进行5-endo-dig环化。用于合成一系列烷基、芳基和杂芳基取代的呋喃的高产率、露天、室温反应条件为该策略提供了独特性。

更新日期:2021-08-06
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