当前位置: X-MOL 学术Gastroenterol. Hepatol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement
The Lancet Gastroenterology & Hepatology ( IF 30.9 ) Pub Date : 2021-08-06 , DOI: 10.1016/s2468-1253(21)00183-7
Mohammed Eslam 1 , Naim Alkhouri 2 , Pietro Vajro 3 , Ulrich Baumann 4 , Ram Weiss 5 , Piotr Socha 6 , Claude Marcus 7 , Way Seah Lee 8 , Deirdre Kelly 9 , Gilda Porta 10 , Mohamed A El-Guindi 11 , Anna Alisi 12 , Jake P Mann 13 , Nezha Mouane 14 , Louise A Baur 15 , Anil Dhawan 16 , Jacob George 1
Affiliation  

The term non-alcoholic fatty liver disease (NAFLD), and its definition, have limitations for both adults and children. The definition is most problematic for children, for whom alcohol consumption is usually not a concern. This problematic definition has prompted a consensus to rename and redefine adult NAFLD associated with metabolic dysregulation to metabolic (dysfunction)-associated fatty liver disease (MAFLD). Similarities, distinctions, and differences exist in the causes, natural history, and prognosis of fatty liver diseases in children compared with adults. In this Viewpoint we, an international panel, propose an overarching framework for paediatric fatty liver diseases and an age-appropriate MAFLD definition based on sex and age percentiles. The framework recognises the possibility of other coexisting systemic fatty liver diseases in children. The new MAFLD diagnostic criteria provide paediatricians with a conceptual scaffold for disease diagnosis, risk stratification, and improved clinical and multidisciplinary care, and they align with a definition that is valid across the lifespan.

更新日期:2021-09-10
down
wechat
bug