The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic stress. In the recent years additional p53-mediated tumour suppression mechanisms have been described, questioning the contribution of its canonical pathway for tumour suppression. These include regulation of alternative cell death modalities (i.e. ferroptosis), cell metabolism and the emerging role in RNA stability. Here we briefly summarize our knowledge on p53 “canonical DNA damage response” and discuss the most relevant recent findings describing potential mechanistic explanation of p53-mediated tumour suppression.

中文翻译：

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了解 p53 肿瘤抑制网络

TP53 基因的突变影响所有人类癌症的一半，导致几种细胞功能的调节受损，包括细胞周期进程和细胞因基因毒性应激而死亡。近年来，已经描述了其他 p53 介导的肿瘤抑制机制，质疑其经典途径对肿瘤抑制的贡献。这些包括调节替代性细胞死亡方式（即铁死亡）、细胞代谢和在 RNA 稳定性中的新作用。在这里，我们简要总结了我们对 p53“经典 DNA 损伤反应”的了解，并讨论了描述 p53 介导的肿瘤抑制的潜在机制解释的最新发现。