This study investigates the fluidization of lactose carriers from a powder bed subjected to a normal force in a channel flow using high-speed imaging, particle image velocimetry (PIV), and high-speed, long-distance microscopy (HS-LDM). Pharmaceutical lactose carriers (LH200 and SV010) with different cohesiveness and fines percentages were examined in this study. Airflow velocities in the range of 1.4 m/s and 7m/s were tested, corresponding to flow rates ranging from 20 to 100 L/min. The use of HS-LDM in tandem with PIV has enabled measurement of the slip factor between particles and conveying airflow as well as metrics that help to identify dose homogeneity as a function of location in the channel flow. The results indicate a lower slip ratio and a larger change in powder particle size bands percentages along with channel height in the region near the powder bed, because of flow recirculation and higher velocity fluctuation observed in that region.

本研究使用高速成像、粒子图像测速 (PIV) 和高速长距离显微镜 (HS-LDM) 研究了粉末床中乳糖载体在通道流中受到法向力的流化。本研究检测了具有不同内聚力和细粉百分比的药用乳糖载体（LH200 和 SV010）。测试了 1.4 m/s 和 7m/s范围内的气流速度，对应的流速范围为 20 到 100 L/min。将 HS-LDM 与 PIV 结合使用，可以测量颗粒和输送气流之间的滑移系数，以及有助于确定剂量均匀性作为通道流中位置函数的指标。 结果表明，由于在该区域观察到流动再循环和更高的速度波动，因此在靠近粉末床的区域中，滑移率较低，粉末粒度带百分比随通道高度的变化较大。