Background

Copper and lipid metabolism are intimately linked, sharing a complex, inverse relationship in the periphery (outside of the central nervous system), which remains to be fully elucidated.

Scope

Copper and lipids have independently been implicated in the pathogenesis of diseases involving dyslipidaemia, including obesity, cardiovascular disease and non-alcoholic fatty liver disease and also in Wilson disease, an inherited disorder of copper overload. Here we review the relationship between copper and lipid regulatory pathways, which are potential druggable targets for therapeutic intervention.

Major conclusions

While the inverse relationship between copper and lipids is apparent, tissue-specific roles for the copper regulatory protein, ATP7B provide further insight into the association between copper and lipid metabolism.

General significance

Understanding the relationship between copper and lipid metabolism is important for identifying druggable targets for diseases with disrupted copper and/or lipid metabolism; and may reveal similar connections within the brain and in neurological diseases with impaired copper and lipid transport.

中文翻译：

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铜和脂质代谢：相互关系

背景

铜和脂质代谢密切相关，在外围（中枢神经系统之外）共享复杂的反向关系，这仍有待充分阐明。

范围

铜和脂质独立地与血脂异常相关疾病的发病机制有关，包括肥胖、心血管疾病和非酒精性脂肪肝，以及威尔逊病，这是一种铜过载的遗传性疾病。在这里，我们回顾了铜和脂质调节通路之间的关系，它们是治疗干预的潜在药物靶点。

主要结论

虽然铜和脂质之间的反比关系很明显，但铜调节蛋白 ATP7B 的组织特异性作用提供了对铜和脂质代谢之间关联的进一步了解。

一般意义

了解铜和脂质代谢之间的关系对于确定铜和/或脂质代谢紊乱疾病的药物靶点很重要；并且可能揭示大脑内和铜和脂质运输受损的神经系统疾病中的类似联系。