Abstract

Biofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to conventional antifungal therapies and suppression of the host immune system, which leads to invasive and recurrent fungal infections. While different features of yeast biofilms are well-described in the literature, the structural and molecular basis of biofilm formation of clinically related filamentous fungi has not been fully addressed. This review aimed to address biofilm formation in clinically relevant filamentous fungi.

摘要

生物膜是附着在生物或非生物表面的高度组织化的微生物群落，被生物膜形成细胞分泌的细胞外基质包围。大多数真菌病原体有助于组织或生物医学装置内的生物膜形成，导致严重和持续的感染。生物膜的临床意义在于增加对常规抗真菌疗法的抵抗力和抑制宿主免疫系统，这会导致侵袭性和复发性真菌感染。虽然文献中充分描述了酵母生物膜的不同特征，但临床相关丝状真菌生物膜形成的结构和分子基础尚未得到充分解决。本综述旨在解决临床相关丝状真菌中的生物膜形成问题。