Organocatalytic Enantioselective [8+4] Cycloadditions of Isobenzofulvenes for the Construction of Bicyclo[4.2.1]nonanes,Chinese Journal of Chemistry

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Organocatalytic Enantioselective [8+4] Cycloadditions of Isobenzofulvenes for the Construction of Bicyclo[4.2.1]nonanes
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2021-08-06 , DOI: 10.1002/cjoc.202100250
Jianhong Zhao ₁ , Xing Zheng ₁ , Yan‐Shan Gao ₁ , Jia Mao ₁ , Shu‐Xiao Wu ₁ , Wu‐Lin Yang ₁ , Xiaoyan Luo ₁ , Wei‐Ping Deng ₁

Affiliation

The [8+4] cycloaddition of indene-2-carbaldehydes with indole-2,3-quinodimethanes and pyrrolidone-3,4-dienes is described, affording indole and pyrrolidone annulated bicyclo[4.2.1]nonanes in a highly peri-, diastereo-, and enantioselective fashion in the presence of a secondary amine catalyst. This reaction, which proceeds through catalytically generated isobenzofulvenes, represents the first asymmetric version of high-order [8+4] cycloaddition.

中文翻译：

用于构建双环[4.2.1]壬烷的异苯并富烯的有机催化对映选择性[8+4]环加成

描述了茚2-甲醛与indole-2,3-quinodimethanes 和pyrrolidone-3,4-dienes 的[8+4] 环加成，在高度环-，在仲胺催化剂存在下的非对映选择性和对映选择性方式。该反应通过催化生成的异苯并富烯进行，代表了高阶 [8+4] 环加成的第一个不对称形式。

更新日期：2021-08-06

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