Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies,Biomaterials Science

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Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-07-29 , DOI: 10.1039/d1bm00896j
Majed Alghamdi _{1,

2} , Mark Gumbleton ₁ , Ben Newland _{1,

3}

Affiliation

Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a very poor prognosis. The standard treatment for newly diagnosed patients involves total tumor surgical resection (if possible), plus irradiation and adjuvant chemotherapy. Despite treatment, the prognosis is still poor, and the tumor often recurs within two centimeters of the original tumor. A promising approach to improving the efficacy of GBM therapeutics is to utilize biomaterials to deliver them locally at the tumor site. Local delivery to GBM offers several advantages over systemic administration, such as bypassing the blood–brain barrier and increasing the bioavailability of the therapeutic at the tumor site without causing systemic toxicity. Local delivery may also combat tumor recurrence by maintaining sufficient drug concentrations at and surrounding the original tumor area. Herein, we critically appraised the literature on local delivery systems based within the following categories: polymer-based implantable devices, polymeric injectable systems, and hydrogel drug delivery systems. We also discussed the negative effect of hypoxia on treatment strategies and how one might utilize local implantation of oxygen-generating biomaterials as an adjuvant to enhance current therapeutic strategies.

中文翻译：

局部递送至恶性脑肿瘤：潜在的基于生物材料的治疗/辅助策略

胶质母细胞瘤 (GBM) 是最具侵袭性的恶性脑肿瘤，预后极差。新诊断患者的标准治疗包括全肿瘤手术切除（如果可能），加上放疗和辅助化疗。尽管进行了治疗，但预后仍然很差，肿瘤往往在原肿瘤两厘米内复发。提高 GBM 治疗效果的一种有前景的方法是利用生物材料将它们局部递送到肿瘤部位。与全身给药相比，局部给药至 GBM 具有多种优势，例如绕过血脑屏障和增加肿瘤部位治疗剂的生物利用度，而不会引起全身毒性。局部给药还可以通过在原始肿瘤区域及其周围维持足够的药物浓度来对抗肿瘤复发。在此，我们批判性地评价了基于以下类别的局部递送系统的文献：基于聚合物的可植入装置、聚合物注射系统和水凝胶药物递送系统。我们还讨论了缺氧对治疗策略的负面影响，以及如何利用局部植入的产氧生物材料作为佐剂来增强当前的治疗策略。

更新日期：2021-08-07

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