当前位置：
X-MOL 学术
›
Biomater. Sci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Preparation and application of quick hemostatic gauze based on biomimetic mineralized thrombin
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-03 , DOI: 10.1039/d1bm00917f Yuting Shi 1, 2 , Xiaoquan Ding 3 , Yufei Cao 1 , Haicun Zhou 4 , Wenwen Yu 4 , Mingsheng Liu 1 , Juanjuan Yin 1 , Hongbin Liu 4 , Jingjing Wang 2 , Congshu Huang 2 , Chenliang Gong 1 , Hua Wei 1 , Guanghui Zhao 1
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-03 , DOI: 10.1039/d1bm00917f Yuting Shi 1, 2 , Xiaoquan Ding 3 , Yufei Cao 1 , Haicun Zhou 4 , Wenwen Yu 4 , Mingsheng Liu 1 , Juanjuan Yin 1 , Hongbin Liu 4 , Jingjing Wang 2 , Congshu Huang 2 , Chenliang Gong 1 , Hua Wei 1 , Guanghui Zhao 1
Affiliation
|
Thrombin is a serine protease known as activated coagulation factor II and is primarily applied as an effective local hemostatic agent. However, its clinical application is hindered by drawbacks, such as high sensitivity to the surrounding environment, instability and poor storage stability, easy inactivation, and low bioavailability. The biological functions of biomacromolecules in harsh environments can be preserved through biomineralization. Despite the success of biomimetic mineralization, limited consideration has been given to the mineral-based methods and the effect of various metal ions on enzyme activity. To explore an efficient technique for biomimetic mineralized thrombin, six kinds of ion/thrombin hybrid microflowers and two kinds of thrombin/MOF were synthesized in this work. The results showed that Zn-HNFs-G exhibits good hemostatic effect and maintains high enzymatic activity when exposed to high-temperature conditions. Meanwhile, Fe-HNFs-G, Thrombin@ZIF-8-G and Thrombin@MAF-7-G possess negligible enzyme protection.
中文翻译：
基于仿生矿化凝血酶的快速止血纱布的制备及应用
凝血酶是一种丝氨酸蛋白酶，称为活化凝血因子 II，主要用作有效的局部止血剂。然而，其对周围环境敏感性高、不稳定和储存稳定性差、易失活、生物利用度低等缺点阻碍了其临床应用。生物大分子在恶劣环境中的生物学功能可以通过生物矿化得以保留。尽管仿生矿化取得了成功，但对基于矿物的方法和各种金属离子对酶活性的影响的考虑有限。为了探索一种有效的仿生矿化凝血酶技术，本工作合成了六种离子/凝血酶杂种微花和两种凝血酶/MOF。结果表明，Zn-HNFs-G在高温条件下表现出良好的止血效果并保持较高的酶活性。同时，Fe-HNFs-G、Thrombin@ZIF-8-G 和 Thrombin@MAF-7-G 的酶保护作用可忽略不计。
更新日期：2021-08-07
中文翻译：
基于仿生矿化凝血酶的快速止血纱布的制备及应用
凝血酶是一种丝氨酸蛋白酶，称为活化凝血因子 II，主要用作有效的局部止血剂。然而，其对周围环境敏感性高、不稳定和储存稳定性差、易失活、生物利用度低等缺点阻碍了其临床应用。生物大分子在恶劣环境中的生物学功能可以通过生物矿化得以保留。尽管仿生矿化取得了成功，但对基于矿物的方法和各种金属离子对酶活性的影响的考虑有限。为了探索一种有效的仿生矿化凝血酶技术，本工作合成了六种离子/凝血酶杂种微花和两种凝血酶/MOF。结果表明，Zn-HNFs-G在高温条件下表现出良好的止血效果并保持较高的酶活性。同时，Fe-HNFs-G、Thrombin@ZIF-8-G 和 Thrombin@MAF-7-G 的酶保护作用可忽略不计。
京公网安备 11010802027423号