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Role of hemagglutinin-esterase protein in SARS-CoV-2 infection?
Cell Biology International ( IF 3.3 ) Pub Date : 2021-08-05 , DOI: 10.1002/cbin.11683
Milad Zandi 1, 2 , Saber Soltani 1, 2
Affiliation  

Dear Editor,

In a published mini-review article in Cell Biology International, the authors considered hemagglutinin-esterase (HE) as a structural protein of SARS-CoV-2 which has roles in the entry and release processes of virus (Tantuoyir & Rezaei, 2020). Coronaviruses are divided in four genera including alpha-, beta-, gamma-, and delta-coronavirus (Yang & Leibowitz, 2015). The five subgenera are recognized within the genus beta-coronavirus (Yang & Leibowitz, 2015). SARS-CoV-2 as a beta-coronavirus in lineage B causes COVID-19 (Letko et al., 2020). It encodes four structural proteins: (1) the spike-surface glycoprotein, (2) the small envelope protein, (3) the membrane glycoprotein, and (4) the nucleocapsid protein, also several nonstructural proteins (Yin, 2020); however, other betacoronaviruses in lineage A such as HCoV-OC43, HCoV-HKU1, BCoV, and MHV encode HE (Yang & Leibowitz, 2015). As a result, according to evidence, the genome of SARS-CoV-2 lacks the HE gene, therefore, HE cannot have a role in SARS-CoV-2 replication.



中文翻译:

血凝素酯酶蛋白在 SARS-CoV-2 感染中的作用?

亲爱的编辑,

Cell Biology International上发表的一篇小型评论文章中,作者认为血凝素酯酶 (HE) 是 SARS-CoV-2 的一种结构蛋白,它在病毒的进入和释放过程中发挥作用(Tantuoyir & Rezaei,  2020 年)。冠状病毒分为四个属,包括 α 冠状病毒、β 冠状病毒、γ 冠状病毒和 δ 冠状病毒(Yang 和 Leibowitz,  2015 年)。这五个亚属在β 冠状病毒属中得到认可(Yang & Leibowitz,  2015 年)。SARS-CoV-2 作为 B 系中的一种 β 冠状病毒导致 COVID-19(Letko 等人,  2020)。它编码四种结构蛋白:(1)刺突表面糖蛋白,(2)小包膜蛋白,(3)膜糖蛋白,和(4)核衣壳蛋白,还有几种非结构蛋白(Yin,  2020);然而,A 谱系中的其他 β 冠状病毒,如 HCoV-OC43、HCoV-HKU1、BCoV 和 MHV 编码 HE(Yang 和 Leibowitz,  2015 年)。因此,根据证据,SARS-CoV-2 的基因组中缺少 HE 基因,因此 HE 无法在 SARS-CoV-2 复制中发挥作用。

更新日期:2021-10-14
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