Introduction

To compare the outcomes of viscoelastic substance injection with air filling in the anterior chamber during foldable capsular vitreous body (FCVB) implant surgery in patients with severe retinal disease.

Methods

Thirty eyes with severe retinal diseases were randomly divided into two groups. In the viscoelastic group, 0.15-0.2 mL of 1.7% sodium hyaluronate was injected into the anterior chamber after FCVB implantation; in the air group, the anterior chamber was maintained by filling the air after FCVB implant surgery. The eyes of treated patients were examined during a 24-week follow-up appointment. Data, including intraocular pressure (IOP), the difference between preoperative and postoperative IOP, and postoperative complications, were recorded.

Results

Data collected from 27 eyes were used in the final analysis. The IOP of the air group was lower than that of the viscoelastic group from the first to third postoperative day (P < 0.01). Moreover, the difference between preoperative and postoperative IOP in the viscoelastic group was significantly smaller than that in the air group from the first to third postoperative day (P < 0.01). After the 1st postoperative week, postoperative IOP values were similar in the two groups (P > 0.05). Postoperative complications in the air group and the viscoelastic group included corneal blood staining (1 eye vs. 0 eyes), transient postoperative diffuse hemorrhage (5 eyes vs. 1 eye), inflammation reaction (9 eyes vs. 4 eyes), and postoperative fibrin exudation (4 eyes vs. 1 eye), respectively.

Conclusion

The use of viscoelastic substances in the anterior chamber during FCVB implant surgery was associated with less fluctuation in postoperative IOP and could reduce postoperative complications.

Registration Number

ChiCTR-TNC-00000396.

中文翻译：

---

可折叠囊状玻璃体 (FCVB) 植入手术中前房注射粘弹性物质与空气填充的比较：一项前瞻性随机对照试验

介绍

比较重度视网膜疾病患者可折叠囊状玻璃体（FCVB）植入手术中粘弹性物质注射与前房空气填充的结果。

方法

30只患有严重视网膜疾病的眼睛被随机分为两组。粘弹性组FCVB植入后前房内注入1.7%透明质酸钠0.15~0.2 mL；空气组在FCVB种植手术后通过充气维持前房。在为期 24 周的随访预约期间检查了治疗患者的眼睛。记录数据，包括眼压（IOP）、术前和术后眼压之间的差异以及术后并发症。

结果

从 27 只眼睛收集的数据用于最终分析。空气组术后1-3天眼压低于粘弹组（P  <0.01）。术后1-3天粘弹组术前术后眼压差异显着小于空气组（P  <0.01）。术后 1 周后，两组术后眼压值相似（P > 0.05)。空气组和粘弹组术后并发症包括角膜血染（1眼对0眼）、术后短暂性弥漫性出血（5眼对1眼）、炎症反应（9眼对4眼）、术后纤维蛋白渗出液（4 只眼对 1 只眼）。

结论

在 FCVB 植入手术期间在前房使用粘弹性物质与术后眼压的波动较小有关，并且可以减少术后并发症。

注册号码

ChiCTR-TNC-00000396。